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Abstract

In the last decades many studies reported evidence for various interplays between DNA repair pathways and the epigenomic landscape. This includes the epigenetically related DNA damageability, the specific damage repair processes and the role of these interconnected mechanisms in (epi)genome maintenance and plasticity.  
Interestingly, the epigenetic context of the damaged genomic regions defines by which repair pathways lesions will be processed. For example, UV-induced DNA damage occurring in genomic regions with an epigenetic landscape allowing transcription are repaired by the Transcription Coupled Repair pathway. Conversely, the compacted heterochromatic regions, un-transcribed or poorly transcribed, are predominantly repaired by the Global Genome Repair. The exact mechanisms by which these repair pathways recognize and process photodamaged DNA sequences wrapped around nucleosomes remain to be better deciphered. In addition, the accurate re-establishment of the epigenomic landscape upon repair appears to be an important step in the maintenance of (epi)genome integrity. We identified a cooperative mode of action of histone post-translational modifications homeostasis and excision repair of UV-induced DNA damage that allows efficient removal of photolesions within constitutive heterochromatin.
 

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Jean Molinier est chercheur au CNRS à l'Institut de Biologie Moléculaire des Plantes (IBMP), à Strasbourg. Il étudie les interactions entre les mécanismes de surveillance du génome et de l'épigénome en réponse à l'irradiation UV.

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