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Gene expression plays pivotal roles in the development of eukaryotic cells and their response to the environment. Failure to precisely program cellular gene expression often has pathological or deleterious consequences. In plants, hormone-responsive transcriptional programs are controlled by nuclear E3 ubiquitin ligases that often function as both hormone receptors and as transcription cofactors.Indeed, E3 ligase-mediated ubiquitination events at or near the chromatin have been reported to regulate the stability of transcription activators and repressors, providing an ON/OFF switch for the control of gene expression.

Our latest findings, however, challenge the simplicity of this model and instead demonstrate that various ubiquitin-processing enzymes dynamically alter ubiquitin chain length and/or type, which determines transcription regulator activity. Upon subsequent arrival at the proteasome, transcription regulators undergo further ubiquitin chain remodelling, which determines their final fate. We will discuss how these diverse ubiquitination events may be linked to changes in the chromatin landscape and control hormone-responsive gene expression programmes.

A propos de l'intervenant :

Steven Spoel a d'abord effectué sa thèse au sein de University de Duke aux Etats-Unis avant de s'installer à l'université d'Edimbourg où il fonde son groupe et prend la tête de l'"Institute of Molecular Plant Sciences". Il est lauréat d'un ERC consolidator grant.

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